TAK-243 preferentially certain to UBA1 about the associated E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced amounts of ubiquitylated proteins, improved markers of proteotoxic stress and DNA hurt tension. In vivo, TAK-243 diminished leukemic stress and focused leukemic stem cells with no https://shahrukhg446pkn5.frewwebs.com/profile