Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators within the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interac... https://kirstenx863qyf0.wiki-cms.com/user