If a dad or mum of your proband is understood to hold the pathogenic variant determined while in the proband, the risk for the sibs of inheriting the pathogenic variant is 50%. Due to reduced penetrance, sibs who inherit the pathogenic variant may or may not build aHUS (see Penetrance). https://5083plate04714.vidublog.com/31926058/the-basic-principles-of-air-handling-unit-ahu-hire