Drug resistance in leprosy is important for Leprosy Control Program. since the WHO-Multidrug regiment (MDT) has been used for global treatment of leprosy for more than two decades already. A Dapsone resistance case in a Multibacillary (MB) leprosy case is reported. The patient was diagnosed and treated in Tajuddin Chalid Hospital Makassar. https://parisnaturalfoodes.shop/product-category/liposomal-vitamin-c-1000/