Analysis into conolidine has resulted in discovery of the opioid receptor in the body referred to as ACKR3/CXCR7. ACKR3 appears to be essentially the most sought after focus on for conolidine, which also disregards the other four classical opioid receptors(3). Conolidine has long been present in the tabernaemontana divaricata https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers